Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases
Identifieur interne : 000343 ( Main/Exploration ); précédent : 000342; suivant : 000344Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases
Auteurs : Yawen Zeng [République populaire de Chine] ; Xiaoying Pu [République populaire de Chine] ; Juan Du [République populaire de Chine] ; Xiaomeng Yang [République populaire de Chine] ; Xia Li [République populaire de Chine] ; Md. Siddikun Nabi Mandal [Bangladesh] ; Tao Yang [République populaire de Chine] ; Jiazhen Yang [République populaire de Chine]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2020.
Abstract
Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular mechanism of six functional ingredients of barley grass (GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan) and grains (
Url:
DOI: 10.1155/2020/3836172
PubMed: 32318238
PubMed Central: 7149453
Affiliations:
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Siddikun Nabi Mandal</name><affiliation wicri:level="1"><nlm:aff id="I2">Bangladesh Wheat and Maize Research Institute, Nashipur, Dinajpur 5200, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Bangladesh Wheat and Maize Research Institute, Nashipur, Dinajpur 5200</wicri:regionArea><wicri:noRegion>Dinajpur 5200</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jiazhen" sort="Yang, Jiazhen" uniqKey="Yang J" first="Jiazhen" last="Yang">Jiazhen Yang</name><affiliation wicri:level="1"><nlm:aff id="I3">Key Laboratory of the Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of the Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32318238</idno><idno type="pmc">7149453</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149453</idno><idno type="RBID">PMC:7149453</idno><idno type="doi">10.1155/2020/3836172</idno><date 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Diseases</title><author><name sortKey="Zeng, Yawen" sort="Zeng, Yawen" uniqKey="Zeng Y" first="Yawen" last="Zeng">Yawen Zeng</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Pu, Xiaoying" sort="Pu, Xiaoying" uniqKey="Pu X" first="Xiaoying" last="Pu">Xiaoying Pu</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Xiaomeng" sort="Yang, Xiaomeng" uniqKey="Yang X" first="Xiaomeng" last="Yang">Xiaomeng Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Mandal, Md Siddikun Nabi" sort="Mandal, Md Siddikun Nabi" uniqKey="Mandal M" first="Md. Siddikun Nabi" last="Mandal">Md. Siddikun Nabi Mandal</name><affiliation wicri:level="1"><nlm:aff id="I2">Bangladesh Wheat and Maize Research Institute, Nashipur, Dinajpur 5200, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Bangladesh Wheat and Maize Research Institute, Nashipur, Dinajpur 5200</wicri:regionArea><wicri:noRegion>Dinajpur 5200</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jiazhen" sort="Yang, Jiazhen" uniqKey="Yang J" first="Jiazhen" last="Yang">Jiazhen Yang</name><affiliation wicri:level="1"><nlm:aff id="I3">Key Laboratory of the Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming 650205, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of the Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming 650205</wicri:regionArea><wicri:noRegion>Kunming 650205</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular mechanism of six functional ingredients of barley grass (GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan) and grains (<italic>β</italic>-glucans, polyphenols, arabinoxylan, phytosterols, tocols, and resistant starch). The antioxidant activity of barley grass and grain has the same and different functional components. These results support findings that barley grain and its grass are the best functional food, promoting ancient Babylonian and Egyptian civilizations, and further show the depending functional ingredients for diet from Pliocene hominids in Africa and Neanderthals in Europe to modern humans in the world. This review paper not only reveals the formation and action mechanism of barley diet overcoming human chronic diseases, but also provides scientific basis for the development of health products and drugs for the prevention and treatment of human chronic diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X. Zheng</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. 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Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bangladesh</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Yawen" sort="Zeng, Yawen" uniqKey="Zeng Y" first="Yawen" last="Zeng">Yawen Zeng</name></noRegion><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><name sortKey="Pu, Xiaoying" sort="Pu, Xiaoying" uniqKey="Pu X" first="Xiaoying" last="Pu">Xiaoying Pu</name><name sortKey="Yang, Jiazhen" sort="Yang, Jiazhen" uniqKey="Yang J" first="Jiazhen" last="Yang">Jiazhen Yang</name><name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name><name sortKey="Yang, Xiaomeng" sort="Yang, Xiaomeng" uniqKey="Yang X" first="Xiaomeng" last="Yang">Xiaomeng Yang</name></country><country name="Bangladesh"><noRegion><name sortKey="Mandal, Md Siddikun Nabi" sort="Mandal, Md Siddikun Nabi" uniqKey="Mandal M" first="Md. 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